LYMPHOID NEOPLASIA WT1 mutations in T-ALL
نویسندگان
چکیده
Valeria Tosello,1 Marc R. Mansour,2 Kelly Barnes,1 Maddalena Paganin,3 Maria Luisa Sulis,1,4 Sarah Jenkinson,2 Christopher G. Allen,2 Rosemary E. Gale,2 David C. Linch,2 Teresa Palomero,1,5 Pedro Real,1,6 Vundavalli Murty,1 Xiaopan Yao,7 Susan M. Richards,8 Anthony Goldstone,9 Jacob Rowe,10 Giuseppe Basso,3 Peter H. Wiernik,11,12 Elisabeth Paietta,11,12 Rob Pieters,13,14 Martin Horstmann,15,16 Jules P. P. Meijerink,13 and Adolfo A. Ferrando1,4,5
منابع مشابه
The Prognostic Impact of WT1 Expression Levels, Mutations, and SNP rs16754 in AML Patients: A Retrospective Cohort Study
Background and Objective: The clinical outcomes and treatment options for acute myeloid leukemia (AML) patients are highly dependent upon molecular markers. In this study, Wilms tumor (WT1) (exons 7 and 9) mutations, SNP rs16754, and WT1 expression levels in 130 random AML patients were screened; FMs-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD), nucleophosmin (NPM1), and CCAAT/...
متن کاملWilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.
In a previous study of acute leukemia, we have shown that WT1 gene mutations occur in both myeloid and biphenotypic subtypes, where they are associated with refractoriness to standard induction chemotherapy. We have now extended this study to a total of 67 cases (34 acute myeloid leukemia [AML], 23 acute lymphoblastic leukemia [ALL], 10 acute undifferentiated leukemia [AUL]/biphenotypic) and fi...
متن کاملWilms’ Tumor (WT1) Gene Mutations Occur Mainly in Acute Myeloid Leukemia and May Confer Drug Resistance
In a previous study of acute leukemia, we have shown that WT1 gene mutations occur in both myeloid and biphenotypic subtypes, where they are associated with refractoriness to standard induction chemotherapy. We have now extended this study to a total of 67 cases (34 acute myeloid leukemia [AML], 23 acute lymphoblastic leukemia [ALL], 10 acute undifferentiated leukemia [AUL]/biphenotypic) and fi...
متن کاملWT1 mutations in T-ALL.
The molecular mechanisms involved in disease progression and relapse in T-cell acute lymphoblastic leukemia (T-ALL) are poorly understood. We used single nucleotide polymorphism array analysis to analyze paired diagnostic and relapsed T-ALL samples to identify recurrent genetic alterations in T-ALL. This analysis showed that diagnosis and relapsed cases have common genetic alterations, but also...
متن کاملPrognostic significance of wilms tumor 1 gene in childhood acute Lymphoblastic Leukemia.
Wilms tumor 1 (WT1) gene is a tumor supressor gene, expressed in malignant and normal hematopoietic progenitor cells. Prognostic significance of this gene in childhood acute lymphoid leukemia (ALL) is not clear. We evaluated the presence of WT1 expression in bone marrow samples of 28 children with de novo ALL at diagnosis by two step RT-PCR. Expression of WT1 gene was detected in 78.5% of patie...
متن کامل